nmda_plot

command
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Published: Oct 25, 2023 License: BSD-3-Clause Imports: 12 Imported by: 0

README

nmda

This plots the NMDA current function from Sanders et al, 2013 and Brunel & Wang (2001) (BW01), which is the most widely used active maintenance model.

See also: https://brian2.readthedocs.io/en/stable/examples/frompapers.Brunel_Wang_2001.html

Also used in: WeiWangWang12, FurmanWang08, NassarHelmersFrank18

Voltage dependence function based on Mg ion blocking is:

1 / (1 + (C/3.57)*exp(-0.062 * vm))

Jahr & Stevens (1990) originally derived this equation, using a Mg+ concentration C of 1 mM, so that factor = 0.28, used in BW01. Urakubo et al. (2008) used a concentration of 1.5 mM, citing Froemke & Dan (2002). Various other sources (Vink & Nechifor) indicate physiological ranges being around 1.2 - 1.4.

g_NMDA from V

In addition to this v-dependent Mg factor, conductance depends on presynaptic glutamate release, which in the basic BW01 model just increments with spikes and decays with a time constant of about 100 msec.

The Urakubo et al (2008) model introduces allosteric dynamics, based on data from Froemke & Dan (2002), which we can capture simply using an inhibitory factor that increments with each spike and decays with a 100 msec time constant. However, their model has an effective Glu-binding decay time of only 30 msec.

References

Documentation

Overview

nmda_plot plots an equation updating over time in a etable.Table and Plot2D.

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